![]() The package is still fairly comprehensive here for the asking price, although the compromises are clear and easy to understand. The Apple Watch SE (second generation) is now the affordable Apple Watch option and replaced the aging Series 3. Not a huge leap forward from Apple Watch Series 7.Some won't require advanced health and safety features.Incredible health tracking capabilities.Read our full Apple Watch Series 8 review.One notable new addition, Low Power Mode, can double the battery life to around 36 hours - though there are natural compromises here.īut overall it's an excellent smartwatch, a true all-rounder, and the best smartwatch out there. ![]() Single-day battery life is still the biggest downside. And it's far more comfortable and less intrusive than the supercharged Apple Watch Ultra.Īll the benefits of watchOS 9 are on board with tracking of sleep stages and excellent workout features – and there's the added health monitoring of ECG, continuous Afib, high/low HR warnings, and SpO2. The edge-to-edge OLED, always on display does wow here, and is one of the top reasons to pick it over the revamped Apple Watch SE. So if the price is putting you off, you may want to look for a Series 7 deal. However, it's a minor upgrade over the Series 7, and the body temperature sensor and car crash detection are the only differences. The Apple Watch Series 8 is the best smartwatch for iPhone users – offering the best mix of features, design, and price of the three models. That also extends to features like Apple Pay or LTE, which Apple does better than its rivals. So by opting for an Apple Watch alternative you might miss out on your favorite 3rd party services, such as Spotify, Google Maps, or your favorite workout-tracking app. The Apple Watch is one of the few smartwatches with a burgeoning App Store, and there’s not a single alternative that can rival this aspect. ![]() However, quality options are available for under $200/£200, should you want to keep costs down. Alternatives are available for less than $99/£99 albeit with serious sacrifices in terms of features and screen tech. And the new Apple Watch Ultra comes in at a whopping $799/£849. PriceĪpple Watch starts at $269/£299 for the SE (2nd gen) and $399/£419 for the Series 8. Most smartwatches now offer a week or more away from the charger, which is a huge draw away from Apple's smartwatch. But you might be surprised to know that it’s a relative outlier. The Apple Watch’s Achilles heel is battery life, and Apple only promises 18 hours between charges (although we usually get 36).
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Rule #6: Homework / Educational Questions must display effort. Rule #3: No BlogSpam / Traffic re-direction. Rule #2: No Certification Brain Dumps / Cheating. r/NetworkingJobs /r/sysadmin /r/ITCareerQuestions /r/CSCareerQuestions /r/ccna /r/juniper /r/jncia /r/ccnp /r/jncis /r/ccdp /r/jncip /r/ccie /r/ccde /r/cisco /r/jncie /r/HomeNetworking /r/TechSupport /r/Network /r/ipv6 /r/networkautomation /r/outages Related IRC Channels Now you can click Proxy checkto test the proxy server you just added. Make sure to specify the SOCKS 5protocol in the Typecolumn. Discussions about ChatGPT and its impact to networking may be allowed. After the first run, you’ll see the window with program configuration and proxy adding feature.ChatGPT is not a source of truth rather it is a word-projection model.Content produced by ChatGPT/LLM is not permitted here. ![]()
![]() Band of Brothers: The primary protagonist's platoon on both sides.Anyone Can Die: Especially striking example, since a primary protagonist gets killed completely unexpectedly.Angsty Surviving Twin: Konstantin Käär, after his younger twin brother Anton is killed by a sniper's bullet.When asked about this by Prokhor, he answers: "It's the end of the road for everybody." They put a sign on the cross that says "31 fallen Red Army soldiers", ensuring that the grave gets dignified treatment by the NKVD troops that will follow. All Are Equal in Death: After the battle between Estonians, Jüri Jõgi orders to bury the fallen of both sides in the same grave.Action Prologue: The film opens right in the middle of the Battle of Tannenberg Line, with Saareste's platoon under Soviet artillery fire.Abandoned War Child: The little girl who is saved by Karl and who ends up adopted by his sister after the war.They are forced to bear the brunt of fighting in the Moonsund operation, leading to heavy casualties while completing the Soviet occupation of Estonia. At the same time, another platoon consisting of Estonian men is fighting on the Soviet side as a part of the 8th Estonian Rifle Corps. During the Tallinn offensive, the German units suddenly fall back from Estonia, leading to the front collapsing. In summer 1944, a platoon of the Estonian SS Division is fighting for life and death during the Battle of Tannenberg Line in Northeastern Estonia. Expect a lot of moral dilemmas when they meet. The ones on the German side hope for a chance to restore the country's independence, while those in the Red Army are mostly just concerned about getting home after years in Russia. The film itself, however, deals with a tragic time in Estonian history as a nation is split between two superpowers, leading to many men fighting on opposing sides. Naturally, this can fuel some controversy in the Western world. The film is remarkable for presenting an Eastern European perspective of the war, by attempting to give both sides of the war an equal light. The film has been acclaimed for its well-done battle scenes and high accuracy in detail, owing to the support of Estonian military and historical experts during the production. It takes place during the Soviet re-occupation of Estonia and follows Estonian soldiers on both sides of the World War II. 1944 is a 2015 Estonian war drama film directed by Elmo Nüganen and written by Leo Kunnas. ![]() There are a number of ways in which you could do this, the simplest would probably be to share via AirDrop and drag it into Photos.
![]() It was also the second time in three years that the Lakers were swept in the playoffs, having been swept by the eventual champion Dallas Mavericks in the 2011 Conference Semifinals. Facing the San Antonio Spurs in the first round, the injury-riddled Lakers were swept in four games to the eventual Western Conference champion. The Lakers qualified for the playoffs on the last day of the season, defeating Houston to finish 45–37 and seeded seventh in the West. The Lakers again overtook Utah in the standings, but Kobe Bryant's season ended after suffering a torn Achilles tendon in the 80th game of the season. After being swept by their crosstown rivals, the Los Angeles Clippers, the Lakers fell a half game behind the Utah Jazz for the final playoff spot. The Lakers started 8–2 after the break, gaining sole possession of a top-8 spot for the first time since December 1, and moving two games over. They were in jeopardy of missing the playoffs after trailing the Houston Rockets at the All-Star break by 3 + 1⁄ 2 games for the eighth and final playoff berth in the Western Conference. Still, the Lakers began the season 15–21 for their worst start since the 1993–94 season. Assistant Bernie Bickerstaff was named the interim coach until Mike D'Antoni took over as the full-time head coach. After an 0–8 preseason record and a 1–4 start to the regular season, Brown was fired. ![]() The season began with head coach Mike Brown changing the Lakers offensive strategy to the Princeton offense. The Lakers were also the top favorite to win the Western Conference. ![]() Widely regarded as a failed superteam mainly due to injuries, the Lakers started out the season as a top 2 favorite to win the championship (the other team being the defending champions Miami Heat who ended up repeating) and the Lakers were projected to win 58 games. Additionally, this was the first season since 2006-07 without longtime point guard Derek Fisher, who had helped the team win its last five championships. They exited the playoffs in the first round for the first time since 2007. However, a weak defense and multiple injuries were the team's biggest problems. Instead, the Lakers struggled to qualify for the playoffs after changing head coaches and implementing multiple offenses. The Lakers acquired All-Stars Steve Nash and Dwight Howard, giving them a starting lineup of five All-Stars consisting of Kobe Bryant, Pau Gasol, Metta World Peace, Nash, and Howard, who were expected to contend for the franchise's 17th NBA championship. The 2012–13 Los Angeles Lakers season was the 65th season of the franchise, its 64th season in the National Basketball Association (NBA), and its 53rd season in Los Angeles. ![]() Jerry Buss (until February 18, his death) The Lakers went back to a strategy that involved earlier involvement from Anthony Davis, which was sorely missing in the Game 2 loss.NBA professional basketball team season 2012–13 Los Angeles Lakers season Before taking a seat in the final stanza, James contributed 11 points in the third quarter, helping the Lakers put the game out of reach. James didn't take a single shot in the first quarter but finally got things going in the second and third quarter. It's likely that Davis will emerge as the top fantasy option for the team, as his increased usage has equated to notches in the win column. The Warriors clearly have a height disadvantage, especially with Kevon Looney's limited involvement and JaMychal Green's inferior play. With the game put away, Russell sat in the fourth quarter, which affected all of the starters' totals.Īgainst the Warriors, it appears that a fast start from Davis is key to the Lakers' success. LeBron James failed to take a shot in the first quarter, which was possibly one reason for Russell's heavy involvement to begin the game. Russell did most of his damage in the first quarter, scoring 13 of his 21 points. ![]() Charge the battery for a minimum of 3 hours.
![]() In most love stories, it takes the form of a “meet cute,” a moment when the main couple first meet and have an emotional connection. Other stories have events that create positive movement. In the same way, for Mark Watney, getting stabbed by an antenna and then stranded on Mars was just the first problem in a long series of problems. For John McClane, the protagonist, terrorists coming to his wife's Christmas party was hardly a positive thing. Some stories have events that begin movement in a negative direct, like Die Hard or The Martian. Stories come in many different shapes, called story arcs (read our complete story arc guide here).The inciting incident's job is to begin the movement of the plot along the actual story arc, whether up or down. Inciting Incidents Can Be Positive or Negative, But They Are Always Interruptions “A character who wants something and is willing to go through conflict to get it.” Here’s Donald Miller’s definition of story in A Million Miles in a Thousand Years: Number the quarter-sections themselves 2, 4, 6 and 8.ĭid you spot the inciting incident in there? ![]() Starting from the 12 o’clock position and going clockwise, number the 4 points where the lines cross the circle: 1, 3, 5 and 7. Here's how Dan Harmon describes the basic structure of the Story Circle:ĭraw a circle and divide it in half vertically. There are many things to like about this structure, which on the surface seems perfect for episodic stories like television sitcoms and also film series. Some plot structure gurus say that the character's desire or need is enough for an inciting incident.ĭan Harmon, the screenwriter and creator of the show Community, developed a framework called the Story Circle theory. The Inciting Incident Is More Than a Desire or Need While it may require several scenes to set up, those prior scenes are usually part of the exposition. It is technically only a moment or a single event, and this moment is almost always set into a single scene. In most cases, the story starts with exposition, but the inciting incident is the second element and the moment when the plot begins. Rising Action/Progressive Complications.Where the Inciting Incident Fits Into Dramatic Structureīefore we go into more detail on what the inciting incident is and share examples of how it’s found in stories, let’s talk about the six elements of dramatic structure that are found in every effective story. We'll talk more about how this unexpected event works in creative writing and screenwriting, but first, let's look at how the inciting incident fits into the dramatic structure. The inciting incident does not need to occur in chapter one, like the hook. The only term I don't think is helpful is the hook, since it combines the inciting incident, which holds a structural place within every story, with the hook, a device used to capture the reader's attention in the first pages of a story. The Problem ( A Million Miles in a Thousand Years by Donald Miller).The Hook ( Seven Point Story Structure by Dan Wells).The Call to Adventure ( The Hero With a Thousand Faces by Joseph Campbell).Other story structure frameworks call this inciting incident by different names, including: But the goal is always created by the inciting incident. Depending on the plot type (which you can read more about here), this story might be an internal goal or an external goal. This unexpected disturbance also complicates the character as they attempt to achieve a scene goal, or want, and that character will spend the rest of the story attempting to achieve it.Įxamples of the goal might be to escape a terrifying natural disaster, to get revenge for the murder of a loved one, to get together with the romantic interest, or even to explore a new worldview opened up by the event. In other words, a situation comes out of nowhere, throws the main character into turmoil, and creates a problem that they have to spend the rest of the plot trying to solve.Īs Robert McKee says, “The inciting incident radically upsets the balance of forces in your protagonist's life.” This begins the story's movement, either in a positive way or negative, that culminates in the climax. ![]() The inciting incident is an unexpected event in a story that upsets the character's status quo. ![]() CD40 ligation, resulting from interactions between CLL cells and follicular T-helper cells, induces NFκB and mTOR activation, resulting in increased expression of antiapoptotic Bcl-2 family members and resistance to apoptosis-inducing agents such as fludarabine and the Bcl-2 antagonist venetoclax ( 32–35). Malignant B cells, including CLL cells, interact with nonmalignant immune cells within the lymph node tumor microenvironment ( 31), which results in inhibition of apoptosis and induction of proliferation. CD40 functions as a costimulatory molecule on healthy B cells, and CD40 stimulation results in maturation and improved antigen-presenting function ( 30). In contrast to toxicity concerns associated with pan-CD3–based strategies, clinical trials have demonstrated the safety of Vγ9Vδ2 T cell–based immunotherapy in hematologic malignancies ( 23–25).ĬD40 is an attractive target for antibody-based antitumor strategies due to its expression on the surface of many B-cell malignancies (i.e., CLL, MM, non-Hodgkin lymphoma, Hodgkin disease, and acute lymphoblastic leukemia) and certain solid malignancies (e.g., renal cell carcinoma, breast carcinoma, melanoma, pancreatic carcinoma refs. Vγ9Vδ2 T cells have also been shown to be cytotoxic to MM and other malignant B cells ( 22). Although we have previously shown that Vγ9Vδ2 T cells can be activated by and subsequently lyse CLL cells, the cytotoxic function of CLL-derived Vγ9Vδ2 T cells is often impaired in a CLL-mediated manner ( 21). Upon activation, Vγ9Vδ2 T cells function as cytotoxic T cells that efficiently produce proinflammatory cytokines and in addition possess antigen-presenting capacity. The Vγ9Vδ2 TCR detects high expression of phosphorylated antigens in the context of butyrophilin (BTN) 3A1, which are commonly upregulated in malignant cells and can be pharmacologically increased using aminobisphosphonates ( 18–20). Vγ9Vδ2 T cells comprise 1% to 10% of peripheral blood T cells and possess a conserved T-cell receptor (TCR) that allows MHC-independent recognition of malignant cells ( 17). The use of a restricted T-cell subset with inherent antitumor properties, such as Vγ9Vδ2 T cells, may circumvent these issues. The current bispecific antibody approaches engage T cells via their CD3 antigen, which is expressed by all T cells, leading to toxicity ( 6–9) as well as the activation of regulatory T cells (Treg), thereby impeding effective T-cell responses ( 13–16). The major challenges associated with these strategies include toxicity and limited response rates (complete response rate in CLL for CAR T-cell therapy: 17%–29% for immune-checkpoint blockade: 0% refs. Current autologous T cell–based strategies include chimeric antigen receptor (CAR) T cells, immune-checkpoint blockade, and bispecific antibodies. Besides targeted therapies, T cell–based therapy represents a promising antitumor approach, specifically in B-cell malignancies ( 3, 4). It may, therefore, represent a potential candidate for the development of novel treatments for B-cell malignancies.ĭespite major improvements in the treatment of B-cell lineage malignancies such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) brought about by novel agents, long-term treatment is required, eventually eliciting toxicity and resistance ( 1, 2). Taken together, our CD40 bispecific γδ T-cell engager increased the sensitivity of leukemic cells to apoptosis and induced a potent Vγ9Vδ2 T cell–dependent antileukemic response. The CD40-bispecific γδ T-cell engager demonstrated lysis of leukemic cells by autologous Vγ9Vδ2 T cells present in patient-derived samples. Selective activation of Vγ9Vδ2 T cells in the presence of CD40 + tumor cells induced potent Vγ9Vδ2 T-cell degranulation, cytotoxicity against CLL and MM cells in vitro, and in vivo control of MM in a xenograft model. The CD40-targeting moiety of the bispecific antibody was selected because it can prevent CD40L-induced prosurvival signaling and reduce CD40-mediated resistance of CLL cells to venetoclax. Here, we describe the generation of a bispecific Vγ9Vδ2 T-cell engager directed against CD40, which, due to its overexpression and biological footprint in malignant B cells, represents an attractive target. Tumor targeting by Vγ9Vδ2 T cells, a conserved T-cell subset with potent intrinsic antitumor properties, mediated by a bispecific antibody represents a novel approach promising high efficacy with limited toxicity. Progress, however, has been hampered by low efficacy and high toxicity. Novel T cell–based therapies for the treatment of B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), are thought to have strong potential. ![]() She’s shown her comedy chops in movies like The Heat, and dramatic efforts in Gravity – a performance which was recognized across the awards circuit. GettyĪfter the role that nabbed her an Oscar (and a Golden Globe, and a SAG Award), Bullock’s only been on an upswing in her capacity as one of America’s sweethearts.Īlthough the year marked the beginning of the end for Bullock and then-husband Jesse James’ relationship, she soon after adopted son Louis as a single parent. Sandra Bullock – Leigh Anne Tuohy Warner Bros. Airways flight due to his size, which he at the time called a wakeup call. He last made headlines more than a year ago after being booted off a U.S. Aaron travels as part of the foundation, speaking at schools and private events. In 2012, Aaron started The Quentin Aaron Foundation, which encourages parents and youth to speak out against bullying. Highlights include a sexy thriller with Evan Ross (the spawn of Diana Ross) called Broken Doll, and an drama with Alan Thicke: It’s Not My Fault and I Don’t Care Anyway. He’s pulling double duty for 2016’s Halfway, executive producing and starring as a recently released convict. It was Blind Side, though, that served as a sufficient launching pad for Aaron’s career in Hollywood. Immediately following the film, he booked an episode of Law and Order: SVU, and then a two-episode recurring arc in One Tree Hill.Īaron then joined the incomparable Nic Cage in the 2014 action thriller Left Behind and has a plethora of films in production including several religious pictures. The 31-year-old got his big break in the 2009 film, although the year before, he had a bit part in Jack Black’s Be Kind Rewind. Quinton Aaron – Michael “Big Mike” Oher Warner Bros. With a cast of Hollywood greats and even music superstars, it’s no surprise the most of the onscreen Tuohy family and friends are still doing well. Sporting a blonde ‘do, Bullock’s no-nonsense portrayal of the real-life Tennessean led the movie (based on aspects of Michael Lewis’ book about the transformation of the offensive tackle position) to box office success and a place on family DVD shelves everywhere. He currently plays for the Carolina Panthers. Using their vast resources, Leigh Anne and Sean helped to transform Oher into a first-round draft pick. Mirror Mirror (2012), following it up by headlining The Mortal Instruments: City of Bones (2013) and Love, Rosie (2014).Sandra Bullock further cemented her place in Hollywood’s elite with 2009’s The Blindside, which was released six years ago today, a heartwarming and true sports film about underprivileged football player Michael Oher. After an impoverished childhood with a junkie mother, Oher was adopted by the wealthy Tuohy family. Roles followed, and she came to worldwide attention when she played the She co-starred as the daughter of Tim McGraw and Sandra Bullock's characters in the massive box office hit The Blind Side (2009). Instance, covering the 2008 US Presidential campaign as a host on theĩ0210 (2008) in 2009. After some early television appearances as a presenter/reporter (for She began writing a column ("NYĬonfidential") for the British magazine Elle Girl in her teens as wellĪs contributing to Seventeen, Teen Vogue, and the Los Angeles Times She graduated from the Harvard-Westlake School, and attended the USC, where she majored in broadcast journalism. Collins performed at the Youth Academy for Dramatic Arts as a child, but her ![]() Her first screen role was at the age of two in the BBC series Growing Pains, in 1992. She is of Russian Jewish (from her maternal grandfather), English, and German descent. Lily moved with her mother to LA at the age of five, after her parents split up. Her father is English musician Phil Collins, while her mother, Jill Tavelman, who is from Los Angeles, California, was president of the Beverly Hills Women's Club for three terms. Lily Jane Collins was born in Guildford, Surrey, England. Divert pedestrians to less slippery walkways and barrier off existing ones.Consider covering walkways eg by an arbour high enough for people to walk through, or use an insulating material on smaller areas overnight.Use grit (see separate article below for more detail) or similar, on areas prone to be slippery in frosty, icy conditions.Put a procedure in place to prevent an icy surface forming and/or keep pedestrians off the slippery surface.There are also smart signs on the market, available to buy at low cost, which display warning messages at 50 and below.Keep up to date by visiting a weather service site such as the Met Office or the Highways England. You need to take action whenever freezing temperatures are forecast.Monitor the temperature, as prevention is key.Identify the outdoor areas used by pedestrians most likely to be affected by ice, for example: - building entrances, car parks, pedestrian walkways, shortcuts, sloped areas and areas constantly in the shade or wet. ![]()
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